Don't get too caught up in where they stand in the box. The truth of the matter is that it really changes little to nothing in terms of what pitch they can/can't hit. In fact, the most important thing they have accomplished is forcing you to call pitches in a pattern they have dictated. Pitch to your pitcher's strengths and stay unpredictable. Hard stuff in and soft stuff away has worked in baseball and softball for many, many years. In-game adjustments are critical for both sides. If my hitter's stance changes your pitch calls then I'll just have them set up on the line before the pitch and back up or open their hips as it comes in. It's always been funny to me that as a pitcher in baseball I was taught that if a hitter crowds the plate then he WANTS the ball inside and the opposite as well. In softball, you hear the opposite taught.